Dr. Magret Bülow

Das bin ich!

CV

  • seit 2019   : Gruppenleiterin am LIMES Institut
  • 2018-2019: unabhängige Wissenschaftlerin am LIMES Institut
  • 2011-2017: PostDoc bei Michael Hoch
  • 2007-2011: Doktorandin bei Ruedi Aebersold, ETH Zürich

Publikationen

  • Paradis M, Kucharowski N, Edwards Faret G, Maya Palacios SJ, Meyer C, Stümpges B, Jamitzky I, Kalinowski J, Thiele C, Bauer R, Paululat A, Sellin J, Bülow MH *. The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Sci Adv. 2022 Jul 22;8(29):eabo0155. doi: 10.1126/sciadv.abo0155.
  • Hänschke L, Heier C, Maya Palacios SJ, Özek HE, Thiele C, Bauer R, Kühnlein RP, Bülow MH * Drosophila Lipase 3 Mediates the Metabolic Response to Starvation and Aging. Front Aging. 2022 Feb 14;3:800153. doi: 10.3389/fragi.2022.800153.
  • Sellin J, Fülle JB, Thiele C, Bauer R, Bülow MH*. Free fatty acid determination as a tool for modeling metabolic diseases in Drosophila. J Insect Physiol. 2020 Jul 27;104090.
  • Di Cara F, Bülow MH, Simmonds A, Rachubinski R. Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy. Mol Biol Cell. 2018 Nov 1;29(22):2766-2783.
  • Sellin J, Wingen C, Gosejacob D, Senyilmaz D, Hänschke L, Büttner S, Meyer M, Bano D, Nicotera P, Teleman AA and Bülow MH*. Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants. PLOS Biol 16(6): e2004893 June 19, 2018.
  • Sociale M, Wulf AL, Breiden B, Klee K, Thielisch M, Eckardt F, Sellin J, Bülow MH et al. Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements. Cell Rep. 2018 Jan 23;22(4):967-978. doi: 10.1016/j.celrep.2017.12.090.
  • Bülow MH*, Wingen C, Senyilmaz D, Gosejacob D, Sociale M, Bauer R, Teleman AA, Hoch M, Sellin S. Unbalanced lipolysis resulting in lipotoxicity provokes mitochondrial damage in peroxisome-deficient Pex19 mutants. Mol Biol Cell. 2018 Feb 15;29(4):396-407.
  • Bülow MH, Bülow TR, Hoch M, Pankratz MJ, Jünger MA. Src tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity. Sci Rep. 2014 Feb 11;4:4048.
  • Bülow MH, Aebersold R, Pankratz MJ, Jünger MA. The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin. PLoS One. 2010 Dec 31;5(12):e15171.
  • Margret Bülow, Brendon D. Parsons and Francesca Di Cara: Drosophila melanogaster as a genetic model system to dissect the mechanisms of disease that lead to neurodegeneration in adrenoleuko-dystrophy. Gerard Lizard (Editor). Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases. Advances in Experimental Medicine and Biology. Springer International Publishing. 2020, pp 145-159. DOI10.1007/978-3-030-60204-8.

Projekte

  • Peroxisomes and neuropeptide secretion: We analyze the role of peroxisomes and one of their biogenesis factors, Pex19, in the secretion of insulin-like peptides from neurons in the brain of Drosophila.
  • ER-mitochondria (+peroxisome) communication: We assess how the communication of organelles of the "redox triangle" affects ROS production in dopaminergic neurons of Drosophila in models for Parkinson's disease.
  • peroxisomes in human neurons during development: We use human neuroblastoma cells to find out how peroxisomal metabolism contributes to axon growth and synaptogenesis.

Auszeichnungen

Funktionen